What cells express LysM?
William Smith
Updated on April 02, 2026
While LysP is expressed in the Paneth cells of the small intestine, LysM is exclusively expressed in myelomonoytic cells including monocytes, macrophages and granulocytes in mice (10). LysM is therefore served as a marker for myelomonoytic cells. In 1999, Clausen et al.
Do neutrophils express LysM?
LysM-cre promotes significant deletion in macrophages, but also in neutrophils. YFP+ cells from mature macrophage populations. Tissue macrophage populations from (A) bronchio-alveolar lavage, (B) peritoneum and (C, D) spleen as defined in Figure 1 were assayed.
How does the CRE LOX system work?
Cre-Lox recombination involves the targeting of a specific sequence of DNA and splicing it with the help of an enzyme called Cre recombinase. Cre-Lox recombination is commonly used to circumvent embryonic lethality caused by systemic inactivation of many genes.
What does FL FL mean?
Summary of Key Points
| FL | |
|---|---|
| Definition: | Fake Laugh |
| Type: | Abbreviation |
| Guessability: | 4: Difficult to guess |
| Typical Users: | Adults and Teenagers |
What does CD11c bind to?
CD11c, a member of the leukointegrin family, is expressed prominently on tissue macrophages and dendritic cells and binds to complement fragment (iC3b), provisional matrix molecules (fibrinogen), and the Ig superfamily cell adhesion molecule, ICAM-1.
Do dendritic cells express CD11c?
Dendritic Cell Phenotype On the cell surface, DCs constitutively express the hematopoietic markers CD45, MHC-II, and CD11c and lack T cell, natural killer (NK) cell, B cell, granulocyte, and erythrocyte lineage markers (see Figure 1 and Table 1).
What is the efficiency of lysmcre deletion in macrophages?
In double mutant mice harboring both the LysMcre allele and one of two different loxP-flanked target genes tested, a deletion efficiency of 83-98% was determined in mature macrophages and near 100% in granulocytes.
Why lysmcre mice?
Taken together, LysMcre mice allow for both specific and highly efficient Cre-mediated deletion of loxP-flanked target genes in myeloid cells. Research Support, Non-U.S. Gov’t
What percentage of DNA is deleted from dendritic cells?
Partial deletion (16%) could be detected in CD11c+ splenic dendritic cells which are closely related to the monocyte/macrophage lineage. In contrast, no significant deletion was observed in tail DNA or purified T and B cells.
