What are the different types of glycogen storage disease?

Types of GSD

• Type I or von Gierke disease. This is the most common form of GSD.
• Type III, Cori disease, or Forbes disease. People with type III don’t have enough of an enzyme called the debranching enzyme, which helps break down glycogen.
• Type IV or Andersen disease. People with type IV form abnormal glycogen.

What causes Forbes disease?

Glycogen storage disease type III (Cori, or Forbes, disease) is caused by mutations in a gene involved in the production of glycogen debranching enzyme. The disease results in cellular accumulation of abnormal, incompletely broken down glycogen molecules, leading to tissue damage, particularly in the liver and muscles.

What is Type 3 liver disease?

Glycogen storage disease type III (also known as GSDIII or Cori disease) is an inherited disorder caused by the buildup of a complex sugar called glycogen in the body’s cells. The accumulated glycogen is structurally abnormal and impairs the function of certain organs and tissues, especially the liver and muscles.

What enzyme causes Cori disease?

The disorder is caused by a defect in the debrancher enzyme gene, which interferes with the breakdown of glycogen (stored sugar) in the muscles and liver. For more, see Causes/Inheritance.

What is the most common glycogen storage disease?

Types of Glycogen Storage Disease Type I (Von Gierke disease) – this is the most common type of glycogen storage disease, and accounts for 90% of all glycogen storage disease cases. Type II (Pompe’s disease, acid maltase deficiency) Type III (Cori’s disease)

What is Anderson’s disease?

Andersen disease is also known as glycogen storage disease (GSD) type IV. It is caused by deficient activity of the glycogen-branching enzyme, resulting in accumulation of abnormal glycogen in the liver, muscle, and/or other tissues.

What is the life expectancy of someone with McArdle’s disease?

The majority of people with McArdle’s Disease will not become disabled. Normally, there is weakness associated with the loss of muscle tissue, but the majority of people remain independent and able to walk. McArdle’s Disease does not affect life expectancy.

What is McArdle?

Glycogen storage disease type V (also known as GSDV or McArdle disease) is an inherited disorder caused by an inability to break down a complex sugar called glycogen in muscle cells. A lack of glycogen breakdown interferes with the function of muscle cells.

How common is glycogen storage disease type 3?

All glycogen storage diseases together affect fewer than 1 in 40,000 persons in the United States. GSD-III has an incidence of about 1 in 100,000.