Is anti-D given in every pregnancy?
Jessica Cortez
Updated on April 02, 2026
Which treatment you’re offered depends on your health authority’s policy. You’ll be offered anti-D each time you’re pregnant. Anti-D is made from the plasma of human blood, given by donors. The manufacture of blood products, including anti-D, is strictly controlled.
How many anti-D injections do I need when pregnant?
Routine antenatal anti-D prophylaxis (RAADP) 2-dose treatment: where you receive 2 injections; 1 during the 28th week of your pregnancy and the other during the 34th week. 1-dose treatment: where you receive an injection of immunoglobulin at some point during weeks 28 to 30 of your pregnancy.
What happens if you don’t have anti-D injection?
If you do not have the anti-D injection, it is possible that you will produce anti-D antibodies. If you become pregnant again and the baby is rhesus positive, the anti-D antibodies might enter the baby’s circulation and attack its blood.
How long do anti-D injections last?
Your midwife will give you an injection of anti-D into a muscle in your thigh or bottom. This will protect you and your baby from harmful antibodies developing, which can happen when your blood mixes with your baby’s blood. The injection works for up to six weeks, and you’ll need another one if the bleeding continues.
Do I need anti D every time I bleed?
Recurrent uterine bleeding Anti-D Ig is unnecessary in women with threatened miscarriage with a viable fetus where bleeding stops completely before 12 weeks. If bleeding is heavy or repeated or where there is associated abdominal pain and gestation approaches 12 weeks a dose of 1500 iu anti-D Ig may be considered.
Do you need anti d injection second pregnancy?
The anti-D injection is safe for both the mother and the baby. If a woman has developed anti-D antibodies in a previous pregnancy (she’s already sensitised) then these immunoglobulin injections don’t help. The pregnancy will be monitored more closely than usual, as will the baby after birth.
When should a woman be given Anti-D injection?
The injection is offered at to rhesus negative women who have rhesus positive partners at 28 and 34 weeks of pregnancy. It can also be given at anytime if there is concern a sensitising event has happened. You can also have the injection after the baby has been born and tests confirm your baby is RhD positive.
Do you need Anti-D injection second pregnancy?